Enantiospecific kinking of DNA by a partially intercalating metal complex.

نویسندگان

Anna Reymer

Bengt Nordén

چکیده

Opposite enantiomers of [Ru(phenanthroline)(3)](2+) affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins.

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